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    Hello Bio Inc clozapine n oxide cno
    Clozapine N Oxide Cno, supplied by Hello Bio Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/clozapine+n-oxide+(cno)/clozapine+n+oxide/pmc13015735-16-0-5
    Average 86 stars, based on 1 article reviews
    clozapine n oxide cno - by Bioz Stars, 2026-09
    86/100 stars

    Images

    Related Articles

    Fluorescence:

    Article Title: RETRACTED: Alcohol drinking alters stress response to predator odor via BNST kappa opioid receptor signaling in male mice
    Article Snippet: 3 mg/kg clozapine N-oxide (CNO; Hello Bio, Princeton, NJ) was dissolved in saline before i.p. administration, 1 ml/100 g, 20 min before testing. c-Fos immunohistochemistry, histology, and microscopy For c-Fos and histological verification, mice were deeply anesthetized with Avertin before transcardial perfusion with phosphate buffered saline and 4% paraformaldehyde.

    Article Title: A neural mechanism for learning from delayed postingestive feedback
    Article Snippet: For the LS activation experiments (Extended Data Fig. ), mice received an i.p. injection of 3 mg kg –1 clozapine N -oxide (CNO; Hellobio, 6149) 45 min before the experiment began.

    Article Title: Alcohol drinking alters stress response to predator odor via BNST kappa opioid receptor signaling in male mice
    Article Snippet: 3 mg/kg clozapine N-oxide (CNO; Hello Bio, Princeton, NJ) was dissolved in saline before i.p. administration, 1 ml/100 g, 20 min before testing.


    Article Title: Neocortical long-range inhibition promotes cortical synchrony and sleep
    Article Snippet: Following habituation, animals received i.p. injection of either Vehicle (saline) or Clozapine N-oxide (CNO, Hello Bio) at 0.5mg/kg, a dose shown not to impact sleep of control animals lacking DREADD , and confirmed in our control experiment ( , ).

    Article Title: Distinct subtypes of astrocytes selectively regulate specific inhibitory synapses
    Article Snippet: To chemogenetically activate astrocytes, clozapine N-oxide (CNO, 10μM, HelloBio) was perfused with the ACSF for 20 minutes.

    Imaging:

    Article Title: RETRACTED: Alcohol drinking alters stress response to predator odor via BNST kappa opioid receptor signaling in male mice
    Article Snippet: 3 mg/kg clozapine N-oxide (CNO; Hello Bio, Princeton, NJ) was dissolved in saline before i.p. administration, 1 ml/100 g, 20 min before testing. c-Fos immunohistochemistry, histology, and microscopy For c-Fos and histological verification, mice were deeply anesthetized with Avertin before transcardial perfusion with phosphate buffered saline and 4% paraformaldehyde.

    Article Title: A neural mechanism for learning from delayed postingestive feedback
    Article Snippet: For the LS activation experiments (Extended Data Fig. ), mice received an i.p. injection of 3 mg kg –1 clozapine N -oxide (CNO; Hellobio, 6149) 45 min before the experiment began.

    Article Title: Alcohol drinking alters stress response to predator odor via BNST kappa opioid receptor signaling in male mice
    Article Snippet: 3 mg/kg clozapine N-oxide (CNO; Hello Bio, Princeton, NJ) was dissolved in saline before i.p. administration, 1 ml/100 g, 20 min before testing.


    Article Title: Neocortical long-range inhibition promotes cortical synchrony and sleep
    Article Snippet: Following habituation, animals received i.p. injection of either Vehicle (saline) or Clozapine N-oxide (CNO, Hello Bio) at 0.5mg/kg, a dose shown not to impact sleep of control animals lacking DREADD , and confirmed in our control experiment ( , ).

    Article Title: Distinct subtypes of astrocytes selectively regulate specific inhibitory synapses
    Article Snippet: To chemogenetically activate astrocytes, clozapine N-oxide (CNO, 10μM, HelloBio) was perfused with the ACSF for 20 minutes.

    Membrane:

    Article Title: RETRACTED: Alcohol drinking alters stress response to predator odor via BNST kappa opioid receptor signaling in male mice
    Article Snippet: 3 mg/kg clozapine N-oxide (CNO; Hello Bio, Princeton, NJ) was dissolved in saline before i.p. administration, 1 ml/100 g, 20 min before testing. c-Fos immunohistochemistry, histology, and microscopy For c-Fos and histological verification, mice were deeply anesthetized with Avertin before transcardial perfusion with phosphate buffered saline and 4% paraformaldehyde.

    Article Title: A neural mechanism for learning from delayed postingestive feedback
    Article Snippet: For the LS activation experiments (Extended Data Fig. ), mice received an i.p. injection of 3 mg kg –1 clozapine N -oxide (CNO; Hellobio, 6149) 45 min before the experiment began.

    Article Title: Alcohol drinking alters stress response to predator odor via BNST kappa opioid receptor signaling in male mice
    Article Snippet: 3 mg/kg clozapine N-oxide (CNO; Hello Bio, Princeton, NJ) was dissolved in saline before i.p. administration, 1 ml/100 g, 20 min before testing.


    Article Title: Neocortical long-range inhibition promotes cortical synchrony and sleep
    Article Snippet: Following habituation, animals received i.p. injection of either Vehicle (saline) or Clozapine N-oxide (CNO, Hello Bio) at 0.5mg/kg, a dose shown not to impact sleep of control animals lacking DREADD , and confirmed in our control experiment ( , ).

    Article Title: Distinct subtypes of astrocytes selectively regulate specific inhibitory synapses
    Article Snippet: To chemogenetically activate astrocytes, clozapine N-oxide (CNO, 10μM, HelloBio) was perfused with the ACSF for 20 minutes.

    Expressing:

    Article Title: RETRACTED: Alcohol drinking alters stress response to predator odor via BNST kappa opioid receptor signaling in male mice
    Article Snippet: 3 mg/kg clozapine N-oxide (CNO; Hello Bio, Princeton, NJ) was dissolved in saline before i.p. administration, 1 ml/100 g, 20 min before testing. c-Fos immunohistochemistry, histology, and microscopy For c-Fos and histological verification, mice were deeply anesthetized with Avertin before transcardial perfusion with phosphate buffered saline and 4% paraformaldehyde.

    Article Title: A neural mechanism for learning from delayed postingestive feedback
    Article Snippet: For the LS activation experiments (Extended Data Fig. ), mice received an i.p. injection of 3 mg kg –1 clozapine N -oxide (CNO; Hellobio, 6149) 45 min before the experiment began.

    Article Title: Alcohol drinking alters stress response to predator odor via BNST kappa opioid receptor signaling in male mice
    Article Snippet: 3 mg/kg clozapine N-oxide (CNO; Hello Bio, Princeton, NJ) was dissolved in saline before i.p. administration, 1 ml/100 g, 20 min before testing.


    Article Title: Neocortical long-range inhibition promotes cortical synchrony and sleep
    Article Snippet: Following habituation, animals received i.p. injection of either Vehicle (saline) or Clozapine N-oxide (CNO, Hello Bio) at 0.5mg/kg, a dose shown not to impact sleep of control animals lacking DREADD , and confirmed in our control experiment ( , ).

    Article Title: Distinct subtypes of astrocytes selectively regulate specific inhibitory synapses
    Article Snippet: To chemogenetically activate astrocytes, clozapine N-oxide (CNO, 10μM, HelloBio) was perfused with the ACSF for 20 minutes.

    Activity Assay:

    Article Title: RETRACTED: Alcohol drinking alters stress response to predator odor via BNST kappa opioid receptor signaling in male mice
    Article Snippet: 3 mg/kg clozapine N-oxide (CNO; Hello Bio, Princeton, NJ) was dissolved in saline before i.p. administration, 1 ml/100 g, 20 min before testing. c-Fos immunohistochemistry, histology, and microscopy For c-Fos and histological verification, mice were deeply anesthetized with Avertin before transcardial perfusion with phosphate buffered saline and 4% paraformaldehyde.

    Article Title: A neural mechanism for learning from delayed postingestive feedback
    Article Snippet: For the LS activation experiments (Extended Data Fig. ), mice received an i.p. injection of 3 mg kg –1 clozapine N -oxide (CNO; Hellobio, 6149) 45 min before the experiment began.

    Article Title: Alcohol drinking alters stress response to predator odor via BNST kappa opioid receptor signaling in male mice
    Article Snippet: 3 mg/kg clozapine N-oxide (CNO; Hello Bio, Princeton, NJ) was dissolved in saline before i.p. administration, 1 ml/100 g, 20 min before testing.


    Article Title: Neocortical long-range inhibition promotes cortical synchrony and sleep
    Article Snippet: Following habituation, animals received i.p. injection of either Vehicle (saline) or Clozapine N-oxide (CNO, Hello Bio) at 0.5mg/kg, a dose shown not to impact sleep of control animals lacking DREADD , and confirmed in our control experiment ( , ).

    Article Title: Distinct subtypes of astrocytes selectively regulate specific inhibitory synapses
    Article Snippet: To chemogenetically activate astrocytes, clozapine N-oxide (CNO, 10μM, HelloBio) was perfused with the ACSF for 20 minutes.

    Activation Assay:

    Article Title: RETRACTED: Alcohol drinking alters stress response to predator odor via BNST kappa opioid receptor signaling in male mice
    Article Snippet: 3 mg/kg clozapine N-oxide (CNO; Hello Bio, Princeton, NJ) was dissolved in saline before i.p. administration, 1 ml/100 g, 20 min before testing. c-Fos immunohistochemistry, histology, and microscopy For c-Fos and histological verification, mice were deeply anesthetized with Avertin before transcardial perfusion with phosphate buffered saline and 4% paraformaldehyde.

    Article Title: A neural mechanism for learning from delayed postingestive feedback
    Article Snippet: For the LS activation experiments (Extended Data Fig. ), mice received an i.p. injection of 3 mg kg –1 clozapine N -oxide (CNO; Hellobio, 6149) 45 min before the experiment began.

    Article Title: Alcohol drinking alters stress response to predator odor via BNST kappa opioid receptor signaling in male mice
    Article Snippet: 3 mg/kg clozapine N-oxide (CNO; Hello Bio, Princeton, NJ) was dissolved in saline before i.p. administration, 1 ml/100 g, 20 min before testing.


    Article Title: Neocortical long-range inhibition promotes cortical synchrony and sleep
    Article Snippet: Following habituation, animals received i.p. injection of either Vehicle (saline) or Clozapine N-oxide (CNO, Hello Bio) at 0.5mg/kg, a dose shown not to impact sleep of control animals lacking DREADD , and confirmed in our control experiment ( , ).

    Article Title: Distinct subtypes of astrocytes selectively regulate specific inhibitory synapses
    Article Snippet: To chemogenetically activate astrocytes, clozapine N-oxide (CNO, 10μM, HelloBio) was perfused with the ACSF for 20 minutes.

    Inhibition:

    Article Title: RETRACTED: Alcohol drinking alters stress response to predator odor via BNST kappa opioid receptor signaling in male mice
    Article Snippet: 3 mg/kg clozapine N-oxide (CNO; Hello Bio, Princeton, NJ) was dissolved in saline before i.p. administration, 1 ml/100 g, 20 min before testing. c-Fos immunohistochemistry, histology, and microscopy For c-Fos and histological verification, mice were deeply anesthetized with Avertin before transcardial perfusion with phosphate buffered saline and 4% paraformaldehyde.

    Article Title: A neural mechanism for learning from delayed postingestive feedback
    Article Snippet: For the LS activation experiments (Extended Data Fig. ), mice received an i.p. injection of 3 mg kg –1 clozapine N -oxide (CNO; Hellobio, 6149) 45 min before the experiment began.

    Article Title: Alcohol drinking alters stress response to predator odor via BNST kappa opioid receptor signaling in male mice
    Article Snippet: 3 mg/kg clozapine N-oxide (CNO; Hello Bio, Princeton, NJ) was dissolved in saline before i.p. administration, 1 ml/100 g, 20 min before testing.


    Article Title: Neocortical long-range inhibition promotes cortical synchrony and sleep
    Article Snippet: Following habituation, animals received i.p. injection of either Vehicle (saline) or Clozapine N-oxide (CNO, Hello Bio) at 0.5mg/kg, a dose shown not to impact sleep of control animals lacking DREADD , and confirmed in our control experiment ( , ).

    Article Title: Distinct subtypes of astrocytes selectively regulate specific inhibitory synapses
    Article Snippet: To chemogenetically activate astrocytes, clozapine N-oxide (CNO, 10μM, HelloBio) was perfused with the ACSF for 20 minutes.

    Injection:

    Article Title: RETRACTED: Alcohol drinking alters stress response to predator odor via BNST kappa opioid receptor signaling in male mice
    Article Snippet: 3 mg/kg clozapine N-oxide (CNO; Hello Bio, Princeton, NJ) was dissolved in saline before i.p. administration, 1 ml/100 g, 20 min before testing. c-Fos immunohistochemistry, histology, and microscopy For c-Fos and histological verification, mice were deeply anesthetized with Avertin before transcardial perfusion with phosphate buffered saline and 4% paraformaldehyde.

    Article Title: A neural mechanism for learning from delayed postingestive feedback
    Article Snippet: For the LS activation experiments (Extended Data Fig. ), mice received an i.p. injection of 3 mg kg –1 clozapine N -oxide (CNO; Hellobio, 6149) 45 min before the experiment began.

    Article Title: Alcohol drinking alters stress response to predator odor via BNST kappa opioid receptor signaling in male mice
    Article Snippet: 3 mg/kg clozapine N-oxide (CNO; Hello Bio, Princeton, NJ) was dissolved in saline before i.p. administration, 1 ml/100 g, 20 min before testing.


    Article Title: Neocortical long-range inhibition promotes cortical synchrony and sleep
    Article Snippet: Following habituation, animals received i.p. injection of either Vehicle (saline) or Clozapine N-oxide (CNO, Hello Bio) at 0.5mg/kg, a dose shown not to impact sleep of control animals lacking DREADD , and confirmed in our control experiment ( , ).

    Article Title: Distinct subtypes of astrocytes selectively regulate specific inhibitory synapses
    Article Snippet: To chemogenetically activate astrocytes, clozapine N-oxide (CNO, 10μM, HelloBio) was perfused with the ACSF for 20 minutes.

    Blocking Assay:

    Article Title: RETRACTED: Alcohol drinking alters stress response to predator odor via BNST kappa opioid receptor signaling in male mice
    Article Snippet: 3 mg/kg clozapine N-oxide (CNO; Hello Bio, Princeton, NJ) was dissolved in saline before i.p. administration, 1 ml/100 g, 20 min before testing. c-Fos immunohistochemistry, histology, and microscopy For c-Fos and histological verification, mice were deeply anesthetized with Avertin before transcardial perfusion with phosphate buffered saline and 4% paraformaldehyde.

    Article Title: A neural mechanism for learning from delayed postingestive feedback
    Article Snippet: For the LS activation experiments (Extended Data Fig. ), mice received an i.p. injection of 3 mg kg –1 clozapine N -oxide (CNO; Hellobio, 6149) 45 min before the experiment began.

    Article Title: Alcohol drinking alters stress response to predator odor via BNST kappa opioid receptor signaling in male mice
    Article Snippet: 3 mg/kg clozapine N-oxide (CNO; Hello Bio, Princeton, NJ) was dissolved in saline before i.p. administration, 1 ml/100 g, 20 min before testing.


    Article Title: Neocortical long-range inhibition promotes cortical synchrony and sleep
    Article Snippet: Following habituation, animals received i.p. injection of either Vehicle (saline) or Clozapine N-oxide (CNO, Hello Bio) at 0.5mg/kg, a dose shown not to impact sleep of control animals lacking DREADD , and confirmed in our control experiment ( , ).

    Article Title: Distinct subtypes of astrocytes selectively regulate specific inhibitory synapses
    Article Snippet: To chemogenetically activate astrocytes, clozapine N-oxide (CNO, 10μM, HelloBio) was perfused with the ACSF for 20 minutes.

    Control:

    Article Title: RETRACTED: Alcohol drinking alters stress response to predator odor via BNST kappa opioid receptor signaling in male mice
    Article Snippet: 3 mg/kg clozapine N-oxide (CNO; Hello Bio, Princeton, NJ) was dissolved in saline before i.p. administration, 1 ml/100 g, 20 min before testing. c-Fos immunohistochemistry, histology, and microscopy For c-Fos and histological verification, mice were deeply anesthetized with Avertin before transcardial perfusion with phosphate buffered saline and 4% paraformaldehyde.

    Article Title: A neural mechanism for learning from delayed postingestive feedback
    Article Snippet: For the LS activation experiments (Extended Data Fig. ), mice received an i.p. injection of 3 mg kg –1 clozapine N -oxide (CNO; Hellobio, 6149) 45 min before the experiment began.

    Article Title: Alcohol drinking alters stress response to predator odor via BNST kappa opioid receptor signaling in male mice
    Article Snippet: 3 mg/kg clozapine N-oxide (CNO; Hello Bio, Princeton, NJ) was dissolved in saline before i.p. administration, 1 ml/100 g, 20 min before testing.


    Article Title: Neocortical long-range inhibition promotes cortical synchrony and sleep
    Article Snippet: Following habituation, animals received i.p. injection of either Vehicle (saline) or Clozapine N-oxide (CNO, Hello Bio) at 0.5mg/kg, a dose shown not to impact sleep of control animals lacking DREADD , and confirmed in our control experiment ( , ).

    Article Title: Distinct subtypes of astrocytes selectively regulate specific inhibitory synapses
    Article Snippet: To chemogenetically activate astrocytes, clozapine N-oxide (CNO, 10μM, HelloBio) was perfused with the ACSF for 20 minutes.

    Gene Expression:

    Article Title: RETRACTED: Alcohol drinking alters stress response to predator odor via BNST kappa opioid receptor signaling in male mice
    Article Snippet: 3 mg/kg clozapine N-oxide (CNO; Hello Bio, Princeton, NJ) was dissolved in saline before i.p. administration, 1 ml/100 g, 20 min before testing. c-Fos immunohistochemistry, histology, and microscopy For c-Fos and histological verification, mice were deeply anesthetized with Avertin before transcardial perfusion with phosphate buffered saline and 4% paraformaldehyde.

    Article Title: A neural mechanism for learning from delayed postingestive feedback
    Article Snippet: For the LS activation experiments (Extended Data Fig. ), mice received an i.p. injection of 3 mg kg –1 clozapine N -oxide (CNO; Hellobio, 6149) 45 min before the experiment began.

    Article Title: Alcohol drinking alters stress response to predator odor via BNST kappa opioid receptor signaling in male mice
    Article Snippet: 3 mg/kg clozapine N-oxide (CNO; Hello Bio, Princeton, NJ) was dissolved in saline before i.p. administration, 1 ml/100 g, 20 min before testing.


    Article Title: Neocortical long-range inhibition promotes cortical synchrony and sleep
    Article Snippet: Following habituation, animals received i.p. injection of either Vehicle (saline) or Clozapine N-oxide (CNO, Hello Bio) at 0.5mg/kg, a dose shown not to impact sleep of control animals lacking DREADD , and confirmed in our control experiment ( , ).

    Article Title: Distinct subtypes of astrocytes selectively regulate specific inhibitory synapses
    Article Snippet: To chemogenetically activate astrocytes, clozapine N-oxide (CNO, 10μM, HelloBio) was perfused with the ACSF for 20 minutes.

    Comparison:

    Article Title: RETRACTED: Alcohol drinking alters stress response to predator odor via BNST kappa opioid receptor signaling in male mice
    Article Snippet: 3 mg/kg clozapine N-oxide (CNO; Hello Bio, Princeton, NJ) was dissolved in saline before i.p. administration, 1 ml/100 g, 20 min before testing. c-Fos immunohistochemistry, histology, and microscopy For c-Fos and histological verification, mice were deeply anesthetized with Avertin before transcardial perfusion with phosphate buffered saline and 4% paraformaldehyde.

    Article Title: A neural mechanism for learning from delayed postingestive feedback
    Article Snippet: For the LS activation experiments (Extended Data Fig. ), mice received an i.p. injection of 3 mg kg –1 clozapine N -oxide (CNO; Hellobio, 6149) 45 min before the experiment began.

    Article Title: Alcohol drinking alters stress response to predator odor via BNST kappa opioid receptor signaling in male mice
    Article Snippet: 3 mg/kg clozapine N-oxide (CNO; Hello Bio, Princeton, NJ) was dissolved in saline before i.p. administration, 1 ml/100 g, 20 min before testing.


    Article Title: Neocortical long-range inhibition promotes cortical synchrony and sleep
    Article Snippet: Following habituation, animals received i.p. injection of either Vehicle (saline) or Clozapine N-oxide (CNO, Hello Bio) at 0.5mg/kg, a dose shown not to impact sleep of control animals lacking DREADD , and confirmed in our control experiment ( , ).

    Article Title: Distinct subtypes of astrocytes selectively regulate specific inhibitory synapses
    Article Snippet: To chemogenetically activate astrocytes, clozapine N-oxide (CNO, 10μM, HelloBio) was perfused with the ACSF for 20 minutes.

    Labeling:

    Article Title: RETRACTED: Alcohol drinking alters stress response to predator odor via BNST kappa opioid receptor signaling in male mice
    Article Snippet: 3 mg/kg clozapine N-oxide (CNO; Hello Bio, Princeton, NJ) was dissolved in saline before i.p. administration, 1 ml/100 g, 20 min before testing. c-Fos immunohistochemistry, histology, and microscopy For c-Fos and histological verification, mice were deeply anesthetized with Avertin before transcardial perfusion with phosphate buffered saline and 4% paraformaldehyde.

    Article Title: A neural mechanism for learning from delayed postingestive feedback
    Article Snippet: For the LS activation experiments (Extended Data Fig. ), mice received an i.p. injection of 3 mg kg –1 clozapine N -oxide (CNO; Hellobio, 6149) 45 min before the experiment began.

    Article Title: Alcohol drinking alters stress response to predator odor via BNST kappa opioid receptor signaling in male mice
    Article Snippet: 3 mg/kg clozapine N-oxide (CNO; Hello Bio, Princeton, NJ) was dissolved in saline before i.p. administration, 1 ml/100 g, 20 min before testing.


    Article Title: Neocortical long-range inhibition promotes cortical synchrony and sleep
    Article Snippet: Following habituation, animals received i.p. injection of either Vehicle (saline) or Clozapine N-oxide (CNO, Hello Bio) at 0.5mg/kg, a dose shown not to impact sleep of control animals lacking DREADD , and confirmed in our control experiment ( , ).

    Article Title: Distinct subtypes of astrocytes selectively regulate specific inhibitory synapses
    Article Snippet: To chemogenetically activate astrocytes, clozapine N-oxide (CNO, 10μM, HelloBio) was perfused with the ACSF for 20 minutes.

    Microscopy:

    Article Title: RETRACTED: Alcohol drinking alters stress response to predator odor via BNST kappa opioid receptor signaling in male mice
    Article Snippet: 3 mg/kg clozapine N-oxide (CNO; Hello Bio, Princeton, NJ) was dissolved in saline before i.p. administration, 1 ml/100 g, 20 min before testing. c-Fos immunohistochemistry, histology, and microscopy For c-Fos and histological verification, mice were deeply anesthetized with Avertin before transcardial perfusion with phosphate buffered saline and 4% paraformaldehyde.

    Article Title: A neural mechanism for learning from delayed postingestive feedback
    Article Snippet: For the LS activation experiments (Extended Data Fig. ), mice received an i.p. injection of 3 mg kg –1 clozapine N -oxide (CNO; Hellobio, 6149) 45 min before the experiment began.

    Article Title: Alcohol drinking alters stress response to predator odor via BNST kappa opioid receptor signaling in male mice
    Article Snippet: 3 mg/kg clozapine N-oxide (CNO; Hello Bio, Princeton, NJ) was dissolved in saline before i.p. administration, 1 ml/100 g, 20 min before testing.


    Article Title: Neocortical long-range inhibition promotes cortical synchrony and sleep
    Article Snippet: Following habituation, animals received i.p. injection of either Vehicle (saline) or Clozapine N-oxide (CNO, Hello Bio) at 0.5mg/kg, a dose shown not to impact sleep of control animals lacking DREADD , and confirmed in our control experiment ( , ).

    Article Title: Distinct subtypes of astrocytes selectively regulate specific inhibitory synapses
    Article Snippet: To chemogenetically activate astrocytes, clozapine N-oxide (CNO, 10μM, HelloBio) was perfused with the ACSF for 20 minutes.

    Laser-Scanning Microscopy:

    Article Title: RETRACTED: Alcohol drinking alters stress response to predator odor via BNST kappa opioid receptor signaling in male mice
    Article Snippet: 3 mg/kg clozapine N-oxide (CNO; Hello Bio, Princeton, NJ) was dissolved in saline before i.p. administration, 1 ml/100 g, 20 min before testing. c-Fos immunohistochemistry, histology, and microscopy For c-Fos and histological verification, mice were deeply anesthetized with Avertin before transcardial perfusion with phosphate buffered saline and 4% paraformaldehyde.

    Article Title: A neural mechanism for learning from delayed postingestive feedback
    Article Snippet: For the LS activation experiments (Extended Data Fig. ), mice received an i.p. injection of 3 mg kg –1 clozapine N -oxide (CNO; Hellobio, 6149) 45 min before the experiment began.

    Article Title: Alcohol drinking alters stress response to predator odor via BNST kappa opioid receptor signaling in male mice
    Article Snippet: 3 mg/kg clozapine N-oxide (CNO; Hello Bio, Princeton, NJ) was dissolved in saline before i.p. administration, 1 ml/100 g, 20 min before testing.


    Article Title: Neocortical long-range inhibition promotes cortical synchrony and sleep
    Article Snippet: Following habituation, animals received i.p. injection of either Vehicle (saline) or Clozapine N-oxide (CNO, Hello Bio) at 0.5mg/kg, a dose shown not to impact sleep of control animals lacking DREADD , and confirmed in our control experiment ( , ).

    Article Title: Distinct subtypes of astrocytes selectively regulate specific inhibitory synapses
    Article Snippet: To chemogenetically activate astrocytes, clozapine N-oxide (CNO, 10μM, HelloBio) was perfused with the ACSF for 20 minutes.

    Saline:

    Article Title: RETRACTED: Alcohol drinking alters stress response to predator odor via BNST kappa opioid receptor signaling in male mice
    Article Snippet: 3 mg/kg clozapine N-oxide (CNO; Hello Bio, Princeton, NJ) was dissolved in saline before i.p. administration, 1 ml/100 g, 20 min before testing. c-Fos immunohistochemistry, histology, and microscopy For c-Fos and histological verification, mice were deeply anesthetized with Avertin before transcardial perfusion with phosphate buffered saline and 4% paraformaldehyde.

    Article Title: A neural mechanism for learning from delayed postingestive feedback
    Article Snippet: For the LS activation experiments (Extended Data Fig. ), mice received an i.p. injection of 3 mg kg –1 clozapine N -oxide (CNO; Hellobio, 6149) 45 min before the experiment began.

    Article Title: Alcohol drinking alters stress response to predator odor via BNST kappa opioid receptor signaling in male mice
    Article Snippet: 3 mg/kg clozapine N-oxide (CNO; Hello Bio, Princeton, NJ) was dissolved in saline before i.p. administration, 1 ml/100 g, 20 min before testing.


    Article Title: Neocortical long-range inhibition promotes cortical synchrony and sleep
    Article Snippet: Following habituation, animals received i.p. injection of either Vehicle (saline) or Clozapine N-oxide (CNO, Hello Bio) at 0.5mg/kg, a dose shown not to impact sleep of control animals lacking DREADD , and confirmed in our control experiment ( , ).

    Article Title: Distinct subtypes of astrocytes selectively regulate specific inhibitory synapses
    Article Snippet: To chemogenetically activate astrocytes, clozapine N-oxide (CNO, 10μM, HelloBio) was perfused with the ACSF for 20 minutes.

    Immunohistochemistry:

    Article Title: RETRACTED: Alcohol drinking alters stress response to predator odor via BNST kappa opioid receptor signaling in male mice
    Article Snippet: 3 mg/kg clozapine N-oxide (CNO; Hello Bio, Princeton, NJ) was dissolved in saline before i.p. administration, 1 ml/100 g, 20 min before testing. c-Fos immunohistochemistry, histology, and microscopy For c-Fos and histological verification, mice were deeply anesthetized with Avertin before transcardial perfusion with phosphate buffered saline and 4% paraformaldehyde.

    Article Title: A neural mechanism for learning from delayed postingestive feedback
    Article Snippet: For the LS activation experiments (Extended Data Fig. ), mice received an i.p. injection of 3 mg kg –1 clozapine N -oxide (CNO; Hellobio, 6149) 45 min before the experiment began.

    Article Title: Alcohol drinking alters stress response to predator odor via BNST kappa opioid receptor signaling in male mice
    Article Snippet: 3 mg/kg clozapine N-oxide (CNO; Hello Bio, Princeton, NJ) was dissolved in saline before i.p. administration, 1 ml/100 g, 20 min before testing.


    Article Title: Neocortical long-range inhibition promotes cortical synchrony and sleep
    Article Snippet: Following habituation, animals received i.p. injection of either Vehicle (saline) or Clozapine N-oxide (CNO, Hello Bio) at 0.5mg/kg, a dose shown not to impact sleep of control animals lacking DREADD , and confirmed in our control experiment ( , ).

    Article Title: Distinct subtypes of astrocytes selectively regulate specific inhibitory synapses
    Article Snippet: To chemogenetically activate astrocytes, clozapine N-oxide (CNO, 10μM, HelloBio) was perfused with the ACSF for 20 minutes.



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    Image Search Results


    M1-WT-HA (n=11-14) (A) , M1-KO (n=13-16) (B) or M1-PD-HA (n=11-14) (C) mice were treated with 1.5 mg/kg scopolamine +/-10 mg/kg VU846 30 mins prior to training in a fear conditioning paradigm. Mice were then returned to the same environment 24 hrs later for contextual memory retrieval whereby a reduced level of freezing indicates impaired memory. The response in vehicle treated animals across strains was also compared (D) . 2-way ANOVA with Tukey’s post-hoc correction for multiple comparisons, *p<0.05, ***p<0.001, ****p<0.0001, ns=not significant. (E ) Representative images of CA1 hippocampal region of HA-tagged M1-WT, M1-DREADD, M1-PD and M1-DREADD-PD stained with HA antibody demonstrating location of the receptor (green). Images at 40X magnification, scale bar = 50 µm

    Journal: bioRxiv

    Article Title: The importance of M1 muscarinic receptor phosphorylation in learning and memory

    doi: 10.64898/2026.03.23.713145

    Figure Lengend Snippet: M1-WT-HA (n=11-14) (A) , M1-KO (n=13-16) (B) or M1-PD-HA (n=11-14) (C) mice were treated with 1.5 mg/kg scopolamine +/-10 mg/kg VU846 30 mins prior to training in a fear conditioning paradigm. Mice were then returned to the same environment 24 hrs later for contextual memory retrieval whereby a reduced level of freezing indicates impaired memory. The response in vehicle treated animals across strains was also compared (D) . 2-way ANOVA with Tukey’s post-hoc correction for multiple comparisons, *p<0.05, ***p<0.001, ****p<0.0001, ns=not significant. (E ) Representative images of CA1 hippocampal region of HA-tagged M1-WT, M1-DREADD, M1-PD and M1-DREADD-PD stained with HA antibody demonstrating location of the receptor (green). Images at 40X magnification, scale bar = 50 µm

    Article Snippet: The drugs utilised in this study were the pan-muscarinic antagonist, to induce a learning and memory (LM) deficit, scopolamine hydrobromide (Sigma) at 0.5-3 mg/kg doses; the M1 positive allosteric modulator (PAM) VU0486846 (VU846) at 10-100 mg/kg; and the M1-DREADD activating ligand clozapine-n-oxide (CNO) (Tocris) at 0.3 mg/kg.

    Techniques: Staining

    (A) Male and female M1-WT-HA (n=11) and M1-PD (n=12) mice were treated with the M1-PAM VU846 30 mins prior to fear conditioning and returned to the chamber 24 hrs later for contextual memory retrieval. 2-way ANOVA ****p<0.0001 effect of strain, no significant effect of drug overall p=0.12, Bonferroni’s post-hoc correction for multiple comparisons between vehicle and VU846 for each strain, ns= not significant. (B & C) Male M1-DREADD mice were treated with 0.3 mg/kg of clozapine-N-oxide (CNO), an orthosteric agonist of the DREADD receptor, or vehicle (n=4-5 per group) 30 mins prior to training in a fear conditioning paradigm and then returned to the same environment 24 hrs later for contextual memory retrieval (B) or presentation of the tone in an altered environment 48 hrs later for cued memory retrieval (C) whereby a reduced level of freezing indicates impaired memory. (D) WT mice (n=7-9 per group) were also treated with 0.3 mg/kg CNO in a separate experiment demonstrating no effect of CNO. 2-way ANOVA with Dunnett’s post-hoc correction for multiple comparisons, ****p<0.0001, all other comparisons p>0.05.

    Journal: bioRxiv

    Article Title: The importance of M1 muscarinic receptor phosphorylation in learning and memory

    doi: 10.64898/2026.03.23.713145

    Figure Lengend Snippet: (A) Male and female M1-WT-HA (n=11) and M1-PD (n=12) mice were treated with the M1-PAM VU846 30 mins prior to fear conditioning and returned to the chamber 24 hrs later for contextual memory retrieval. 2-way ANOVA ****p<0.0001 effect of strain, no significant effect of drug overall p=0.12, Bonferroni’s post-hoc correction for multiple comparisons between vehicle and VU846 for each strain, ns= not significant. (B & C) Male M1-DREADD mice were treated with 0.3 mg/kg of clozapine-N-oxide (CNO), an orthosteric agonist of the DREADD receptor, or vehicle (n=4-5 per group) 30 mins prior to training in a fear conditioning paradigm and then returned to the same environment 24 hrs later for contextual memory retrieval (B) or presentation of the tone in an altered environment 48 hrs later for cued memory retrieval (C) whereby a reduced level of freezing indicates impaired memory. (D) WT mice (n=7-9 per group) were also treated with 0.3 mg/kg CNO in a separate experiment demonstrating no effect of CNO. 2-way ANOVA with Dunnett’s post-hoc correction for multiple comparisons, ****p<0.0001, all other comparisons p>0.05.

    Article Snippet: The drugs utilised in this study were the pan-muscarinic antagonist, to induce a learning and memory (LM) deficit, scopolamine hydrobromide (Sigma) at 0.5-3 mg/kg doses; the M1 positive allosteric modulator (PAM) VU0486846 (VU846) at 10-100 mg/kg; and the M1-DREADD activating ligand clozapine-n-oxide (CNO) (Tocris) at 0.3 mg/kg.

    Techniques:

    Male M1-DREADD mice were treated with 0.01 - 0.3 mg/kg of clozapine-N-oxide (CNO), an orthosteric agonist of the DREADD receptor, or vehicle (n=5-9 per group) 30 mins prior to training in a fear conditioning paradigm and then returned to the same environment 24 hrs later for contextual memory retrieval. Data presented as freezing level normalised to the highest freezing response. One way ANOVA with Bonferroni’s post hoc correction for multiple comparisons to vehicle treatment group *p<0.05. All other comparisons not significant.

    Journal: bioRxiv

    Article Title: The importance of M1 muscarinic receptor phosphorylation in learning and memory

    doi: 10.64898/2026.03.23.713145

    Figure Lengend Snippet: Male M1-DREADD mice were treated with 0.01 - 0.3 mg/kg of clozapine-N-oxide (CNO), an orthosteric agonist of the DREADD receptor, or vehicle (n=5-9 per group) 30 mins prior to training in a fear conditioning paradigm and then returned to the same environment 24 hrs later for contextual memory retrieval. Data presented as freezing level normalised to the highest freezing response. One way ANOVA with Bonferroni’s post hoc correction for multiple comparisons to vehicle treatment group *p<0.05. All other comparisons not significant.

    Article Snippet: The drugs utilised in this study were the pan-muscarinic antagonist, to induce a learning and memory (LM) deficit, scopolamine hydrobromide (Sigma) at 0.5-3 mg/kg doses; the M1 positive allosteric modulator (PAM) VU0486846 (VU846) at 10-100 mg/kg; and the M1-DREADD activating ligand clozapine-n-oxide (CNO) (Tocris) at 0.3 mg/kg.

    Techniques: